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ea0099p115 | Pituitary and Neuroendocrinology | ECE2024

The value of digital quantification of somatostatin receptor subtypes 2 and 5 immunostaining in GH-secreting pituitary tumors

Campana Claudia , Amaru Jessica , Milioto Angelo , Nista Federica , M. van Koetsveld Peter , Iyer Anand , Arvigo Marica , Ferone Diego , J. Hofland Leo , Gatto Federico

Introduction: Immunohistochemistry (IHC) of somatostatin receptor subtype 2 (SST2) is a predictive factor for first-generation somatostatin receptor ligand (fg-SRL) response in acromegaly patients. A semi-quantitative immunoreactivity score, IRS, has been proposed as the gold-standard to evaluate SST2 IHC expression. Recently, our group developed a quantitative method to determine SST2 expression using an open-source digital image analysis (DIA...

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The value of digital quantification of somatostatin receptor subtypes 2 and 5 immunostaining in GH-secreting pituitary tumors

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